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ATCC mda-mb-231
Mda Mb 231, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 3682 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mda+mb+231+cells/MDA-MB-231/custom%40crm-htb-26%4010%2E1016%2Fj%2Esajb%2E2026%2E07%2E014
Average 99 stars, based on 3682 article reviews

mda-mb-231 - by Bioz Stars, 2026-09

99/100 stars

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Multiple Displacement Amplification:

Article Title: Targeting PD-L1 and disrupting Siglec-9 cooperatively potentiate macrophage phagocytosis of breast cancer via a trispecific macrophage engager (TriME).
Article Snippet: MDMs were stained with antibodies specific to macrophage markers (CD45, CD14, CD16 and CD11b, BioLegend, San Diego, CA, USA) and analyzed by flow cytometry (Fortessa, BD Biosciences, San Jose, CA, USA). .. THP− 1 cells (TIB− 202), HEK293T cells (CRL− 3216), MDA-MB− 231 cells (HTB− 26), and NK92 cells were obtained from the American Type Culture Collection (ATCC, American Type Culture Collection, Manassas, VA, USA). .. THP− 1 cells were maintained in complete RPMI− 1640 medium: RPMI− 1640 supplemented with 10%FBS, 1XGlutaMAX (Thermo Fisher Scientific, Waltham, MA, USA), 100 U/mL penicillin, and 100 μg/ mL streptomycin (Gibco, Grand Island, NY, USA).

Article Title: Analyzing cell migration history in vivo using fluorescent fibrillar collagen trails.
Article Snippet: Cell membrane associated tdTomato expressing cardiac cells were isolated from the heart of mTmG transgenic mice ordered from Jackson Laboratory (Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J, strain # 007576) by collagenase dissociation. .. Aortic smooth muscle cell line (Cat# PCS-100-012), MDA-MB-231 cells (Cat# CRM-HTB-26) were purchased from American Type Culture Collection (Manasses, VA). .. EO771 cells were ordered from CH3 BioSystems LLC (Cat# 94A001, Amherst, NY).

Article Title: Mixed Lineage Kinase Suppression in Triple-Negative Breast Cancer: Identification of a Dual Inhibitor Targeting MLK3 and NAMPT.
Article Snippet: Triple-negative breast cancer (TNBC) is aggressive and lacks targeted therapeutic options.. Mixed lineage kinase 3 (MLK3) plays a key role in TNBC progression.. To enhance the therapeutic impact of MLK3 inhibition in TNBC, a novel MLK3 inhibitor scaffold was optimized to incorporate inhibition of NAMPT, often upregulated in TNBC to meet the increased demand for NAD+.

Article Title: Impact of the polymer side chain chemistry on interactions of amino-acid-derived polyelectrolytes with cells.
Article Snippet: .. MDA-MB-231 cells (HTB-26, ATCC) were maintained in DMEM/F12 cell culture medium, HCC-78 cells were cultured in RPMI 1640 medium, and NIH-3T3 and L929 were cultured in Dulbecco’s Modified Eagle’s Medium low glucose. ..

Article Title: TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells.
Article Snippet: T47D cells were cultured in RPMI1640 (ATCC, 30-2001) with 10% FBS (Gibco, A52558-01) and 10 μg ml−1 insulin (Lonza, BE02-033E20). .. MCF-7 cells were cultured in EMEM (ATCC, 30-2003) supplemented with 10% FBS and 10 μg ml−1 insulin, and MDA-MB-231 cells were cultured in DMEM (ATCC, 30-2002) supplemented with 10% FBS. .. MCF-10A cells were cultured in DMEM-F12 (ATCC, 30-2006) supplemented with 5% horse serum (Millipore, H1138), 20 ng ml−1 EGF (Rockland, 009-001-C26), 0.5 mg ml−1 hydrocortisone (VWR, 1315004), 100 ng ml−1 cholera toxin (Millipore, 9012-63-9), 10 μg ml−1 insulin and 1% penicillin–streptomycin (VWR, 10220-718).

Article Title: Piezo1 links cytoskeletal remodeling to differential YAP and β-catenin signaling in response to mechanical cues
Article Snippet: .. Human breast cancer MCF-7 and MDA-MB-231 cells were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA). .. Both MCF-7 and MDA-MB-231 cell lines were cultured in Dulbecco’s Modified Eagle Medium (DMEM; Thermo Fisher Scientific, NY, USA) supplemented with 10% fetal bovine serum (FBS; Thermo Fisher Scientific, NY, USA) at 37 °C in a humidified atmosphere with 5% CO2.

Article Title: Amphiregulin drives EGFR-dependent genome stability in colorectal cancer and represents a targetable vulnerability.
Article Snippet: Amphiregulin (AREG) functions as an epidermal growth factor receptor (EGFR) ligand that modulates signaling and supports nuclear processes involved in DNA replication and repair in colorectal cancer (CRC).. Immunohistochemistry and western blot revealed high expression of AREG in CRC tumors compared to other CRCs.. Our findings indicate that AREG translocates into the nucleus, a process potentially facilitated by the inhibition of endocytosis.

Article Title: Ligands of the fsh hormone receptor in the diagnosis and treatment of tumors
Article Snippet: .. Analysis of the Cell Growth Curves CAOV-3 cells were cultured in DMEM supplemented with 10% fetal bovine serum and 2 mM glutamine (Sigma), MDA-MB-231 cells in L15 medium (ATCC) supplemented with 10% fetal bovine serum. .. OVCAR-3 cells were cultured in RPMI supplemented with 20% fetal bovine serum and 2 mM glutamine and 0.01 mg/ml insulin (Sigma).

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CEP exerts cytotoxicity in TNBC cells. (A) Chemical structure of CEP. (B) CEP inhibited TNBC cell viability. The effect of CEP treatment on TNBC cell viability after 24, 48 and 72 h. (C) CEP inhibited <t>clonogenicity</t> <t>of</t> <t>MDA-MB-231</t> and Hs578T cells. n=3; *P < 0.05, **P < 0.01 and ***P < 0.001 vs. control. CEP, cepharanthine; TNBC, triple-negative breast cancer.

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Journal: Molecular Medicine Reports

Article Title: Cepharanthine inhibits lysosomes and induces apoptosis in triple-negative breast cancer cells

doi: 10.3892/mmr.2026.13899

Figure Lengend Snippet: CEP exerts cytotoxicity in TNBC cells. (A) Chemical structure of CEP. (B) CEP inhibited TNBC cell viability. The effect of CEP treatment on TNBC cell viability after 24, 48 and 72 h. (C) CEP inhibited clonogenicity of MDA-MB-231 and Hs578T cells. n=3; *P < 0.05, **P < 0.01 and ***P < 0.001 vs. control. CEP, cepharanthine; TNBC, triple-negative breast cancer.

Article Snippet: The TNBC cell lines MDA-MB-231 (cat. no. CL-0150; Procell Life Science & Technology Co., Ltd.) and Hs578T (cat. no. CL-0114; Procell Life Science & Technology Co., Ltd.) were cultured in high-glucose DMEM medium (cat. no. C11965500BT; Gibco; Thermo Fisher Scientific, Inc.), supplemented with 10% fetal bovine serum (cat. no. 164210; Procell Life Science & Technology Co., Ltd.) and 1% penicillin/streptomycin (cat. no. 15140122; Gibco; Thermo Fisher Scientific, Inc.).

Techniques: Control

CEP induces apoptosis in triple-negative breast cancer cells. Flow cytometric quantification of apoptosis induced by CEP in (A) MDA-MB-231 and (B) Hs578T cells (n=3; 48 h). **P<0.01 and ***P < 0.001 vs. control. CEP, cepharanthine; ns, not significant.

Journal: Molecular Medicine Reports

Article Title: Cepharanthine inhibits lysosomes and induces apoptosis in triple-negative breast cancer cells

doi: 10.3892/mmr.2026.13899

Figure Lengend Snippet: CEP induces apoptosis in triple-negative breast cancer cells. Flow cytometric quantification of apoptosis induced by CEP in (A) MDA-MB-231 and (B) Hs578T cells (n=3; 48 h). **P<0.01 and ***P < 0.001 vs. control. CEP, cepharanthine; ns, not significant.

Techniques: Control

CEP induces ΔΨm loss in triple-negative breast cancer cells. (A) MDA-MB-231 (10 µM; n=3; 24 h) and (B) Hs578T cells (4 µM; n=3; 24 h). Scale bar, 100 µM. CEP, cepharanthine.

Journal: Molecular Medicine Reports

Article Title: Cepharanthine inhibits lysosomes and induces apoptosis in triple-negative breast cancer cells

doi: 10.3892/mmr.2026.13899

Figure Lengend Snippet: CEP induces ΔΨm loss in triple-negative breast cancer cells. (A) MDA-MB-231 (10 µM; n=3; 24 h) and (B) Hs578T cells (4 µM; n=3; 24 h). Scale bar, 100 µM. CEP, cepharanthine.

Techniques:

CEP upregulates NOXA and downregulates Bcl-2 expression in triple-negative breast cancer cells. CEP upregulated NOXA and downregulated Bcl-2 expression in (A) MDA-MB-231 cells (n=3; 24 h) and (B) Hs578T cells (n=3; 24 h). *P<0.05, **P<0.01 and ***P<0.001 vs. control. CEP, cepharanthine; NOXA, phorbol-12-myristate-13-acetate-induced protein 1; ns, not significant.

Journal: Molecular Medicine Reports

Article Title: Cepharanthine inhibits lysosomes and induces apoptosis in triple-negative breast cancer cells

doi: 10.3892/mmr.2026.13899

Figure Lengend Snippet: CEP upregulates NOXA and downregulates Bcl-2 expression in triple-negative breast cancer cells. CEP upregulated NOXA and downregulated Bcl-2 expression in (A) MDA-MB-231 cells (n=3; 24 h) and (B) Hs578T cells (n=3; 24 h). *P<0.05, **P<0.01 and ***P<0.001 vs. control. CEP, cepharanthine; NOXA, phorbol-12-myristate-13-acetate-induced protein 1; ns, not significant.

Techniques: Expressing, Control

Proteomic profiling of MDA-MB-231 cells following CEP treatment. (A) The 20 most significantly downregulated Gene Ontology cellular components with CEP treatment. (B) Significantly downregulated Kyoto Encyclopedia of Genes and Genomes pathways with CEP treatment. CEP, cepharanthine.

Journal: Molecular Medicine Reports

Article Title: Cepharanthine inhibits lysosomes and induces apoptosis in triple-negative breast cancer cells

doi: 10.3892/mmr.2026.13899

Figure Lengend Snippet: Proteomic profiling of MDA-MB-231 cells following CEP treatment. (A) The 20 most significantly downregulated Gene Ontology cellular components with CEP treatment. (B) Significantly downregulated Kyoto Encyclopedia of Genes and Genomes pathways with CEP treatment. CEP, cepharanthine.

Techniques:

CEP treatment activates TFEB in triple-negative breast cancer cells. (A) CEP triggers TFEB nuclear translocation in MDA-MB-231 cells (10 µM; 24 h). (B) CEP triggers TFEB nuclear translocation in Hs578T cells (4 µM; 24 h). Scale bar, 25 µm; n=5. **P<0.01 vs. control. TFEB, transcription factor EB; CEP, cepharanthine.

Journal: Molecular Medicine Reports

Article Title: Cepharanthine inhibits lysosomes and induces apoptosis in triple-negative breast cancer cells

doi: 10.3892/mmr.2026.13899

Figure Lengend Snippet: CEP treatment activates TFEB in triple-negative breast cancer cells. (A) CEP triggers TFEB nuclear translocation in MDA-MB-231 cells (10 µM; 24 h). (B) CEP triggers TFEB nuclear translocation in Hs578T cells (4 µM; 24 h). Scale bar, 25 µm; n=5. **P<0.01 vs. control. TFEB, transcription factor EB; CEP, cepharanthine.

Techniques: Translocation Assay, Control

CEP does not induce LMP, increase lysosomal pH or destabilize lysosomal membrane-bound enzymes in triple-negative breast cancer cells. (A) CEP does not induce LMP, as evidenced by a dispersion of dextran, in MDA-MB-231 (10 µM; 24 h) and Hs578T cells (4 µM; 24 h). Scale bar, 25 µm. (B) CEP does not elevate lysosomal pH in the MDA-MB-231 (10 µM; 24 h) and Hs578T cell lines (4 µM; 24 h). Scale bar, 25 µm. (C) CEP does not induce lysosomal membrane-bound enzymes degradation in the MDA-MB-231 (10 µM; n=3; 24 h) and Hs578T cell lines (4 µM; n=3; 24 h). CEP, cepharanthine; ASAH1, acid ceramidase; SMPD1, sphingomyelin phosphodiesterase; ns, not significant.

Journal: Molecular Medicine Reports

Article Title: Cepharanthine inhibits lysosomes and induces apoptosis in triple-negative breast cancer cells

doi: 10.3892/mmr.2026.13899

Figure Lengend Snippet: CEP does not induce LMP, increase lysosomal pH or destabilize lysosomal membrane-bound enzymes in triple-negative breast cancer cells. (A) CEP does not induce LMP, as evidenced by a dispersion of dextran, in MDA-MB-231 (10 µM; 24 h) and Hs578T cells (4 µM; 24 h). Scale bar, 25 µm. (B) CEP does not elevate lysosomal pH in the MDA-MB-231 (10 µM; 24 h) and Hs578T cell lines (4 µM; 24 h). Scale bar, 25 µm. (C) CEP does not induce lysosomal membrane-bound enzymes degradation in the MDA-MB-231 (10 µM; n=3; 24 h) and Hs578T cell lines (4 µM; n=3; 24 h). CEP, cepharanthine; ASAH1, acid ceramidase; SMPD1, sphingomyelin phosphodiesterase; ns, not significant.

Techniques: Membrane, Dispersion

CEP binds to and inhibits lysosomal enzymes. (A) Structurally altered peptides in the MDA-MB-231 cell line upon CEP treatment (10 µM, 1 h; FC >1.5 or <0.667, false discovery rate <1, P<0.01; n=3). (B) CEP treatment suppresses the maturation of CTSB and CTSD (24 h). *P<0.05, **P<0.01 and ***P<0.001 vs. control. CEP, cepharanthine; FC, fold change; CTSD, cathepsin D; CTSB, cathepsin B; pro-CTSB pro-cathepsin B; pro-CTSD, pro-cathepsin D; i-CTSB, inactive cathepsin B; m-CTSB, mature cathepsin B; m-CTSD, mature cathepsin D.

Journal: Molecular Medicine Reports

Article Title: Cepharanthine inhibits lysosomes and induces apoptosis in triple-negative breast cancer cells

doi: 10.3892/mmr.2026.13899

Figure Lengend Snippet: CEP binds to and inhibits lysosomal enzymes. (A) Structurally altered peptides in the MDA-MB-231 cell line upon CEP treatment (10 µM, 1 h; FC >1.5 or <0.667, false discovery rate <1, P<0.01; n=3). (B) CEP treatment suppresses the maturation of CTSB and CTSD (24 h). *P<0.05, **P<0.01 and ***P<0.001 vs. control. CEP, cepharanthine; FC, fold change; CTSD, cathepsin D; CTSB, cathepsin B; pro-CTSB pro-cathepsin B; pro-CTSD, pro-cathepsin D; i-CTSB, inactive cathepsin B; m-CTSB, mature cathepsin B; m-CTSD, mature cathepsin D.

Techniques: Control

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